Exploiting synthetic-lethal interactions to target triple-negative breast cancer

This proposed research is focused on better understanding and tackling triple-negative breast cancer (TNBC), for which currently no molecularly targeted therapeutic strategies are available. We will combine state-of-the-art preclinical experimental model systems and powerful bioinformatics approaches to identify ways to induce cell death selectively in triple-negative tumor cells while sparing non-tumorigenic cells.