Exploring the angiogenesis-to-fibrosis transition in ischemic retinopathies

This proposal aims to study the process of retinal vascular damage that leads to retinal blindness from lack of oxygen and nutrients. The experiments use a range of mouse models that replicate the different stages of human disease, allowing the team to study specific markers that promote scar formation. Success of this proposal will lead to the development of non-invasive therapies that can prevent advanced scar tissue formation in the retina, along with their devastating and blinding complications.