Fellowship for Marc Sala in support of: The Role of JNK in Hypoxia-Induced Pulmonary Hypertension

Project: Research project

Description

Pulmonary hypertension is the condition of having elevated blood pressure of the artery leading from the heart into the lungs. It is a complication of lung diseases such as chronic obstructive pulmonary disease (chronic bronchitis or emphysema), interstitial lung diseases, and sleep apnea. Its diagnosis is associated with increased risk of death and treatment options are very limited. This proposal seeks to define the role of the group of proteins known as c-Jun N-terminal kinases (JNKs) in development of pulmonary hypertension. These studies may lead to a new target for future drug discovery endeavors in the treatment of pulmonary hypertension, thereby reducing the burden of this disease on the lives of people with lung diseases.
StatusFinished
Effective start/end date7/1/166/30/18

Funding

  • American Lung Association (RT-416649)

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Pulmonary Hypertension
Phosphotransferases
Lung Diseases
JNK Mitogen-Activated Protein Kinases
Chronic Bronchitis
Interstitial Lung Diseases
Emphysema
Sleep Apnea Syndromes
Drug Discovery
Chronic Obstructive Pulmonary Disease
Arteries
Blood Pressure
Lung
Hypoxia
Proteins