Pulmonary hypertension is the condition of having elevated blood pressure of the artery leading from the heart into the lungs. It is a complication of lung diseases such as chronic obstructive pulmonary disease (chronic bronchitis or emphysema), interstitial lung diseases, and sleep apnea. Its diagnosis is associated with increased risk of death and treatment options are very limited. This proposal seeks to define the role of the group of proteins known as c-Jun N-terminal kinases (JNKs) in development of pulmonary hypertension. These studies may lead to a new target for future drug discovery endeavors in the treatment of pulmonary hypertension, thereby reducing the burden of this disease on the lives of people with lung diseases.
|Effective start/end date||7/1/16 → 6/30/18|
- American Lung Association (RT-416649)
JNK Mitogen-Activated Protein Kinases
Interstitial Lung Diseases
Sleep Apnea Syndromes
Chronic Obstructive Pulmonary Disease