Fellowship in support of Marc Sala: Program for Adult Care Excellence (PACE) Program

Project: Research project

Description

The mission of the Cystic Fibrosis Foundation is to improve the quality of life of CF patients as
well as to facilitate development of therapies and eventually a cure for CF. To this end, the
proposed mentoring plan for Dr. Marc Sala will be multi-faceted in nature, comprised by clinical
training supplemented by relevant coursework as well as support for his ongoing research efforts.
Dr. Sala has assembled a mentoring committee to prepare him for an academic career as a clinician
and physician scientist specializing in CF. Dr. Sala’s committee will consist of co-chairs Dr. Manu
Jain, Dr. Adrienne Savant, and Dr. Jing Liu. Dr. Manu Jain is a Professor of Medicine and has
served as Director of the Northwestern University Adult CF Program since its inception in 1999.
He is an active participant in the ongoing research projects through our CF center. He holds a
Masters in Clinical Investigation and also runs a productive research lab. Dr. Adrienne Savant is an
Associate Professor of Pediatrics and the Director of the Cystic Fibrosis Center. Dr. Jing Liu, PhD,
is an Assistant Professor in the Division of Pulmonary and Critical Care Medicine, is a recognized
leader in the fields of biochemistry, cell biology, and molecular biology as they relate to pulmonary
diseases, and has been Dr. Sala’s primary research mentor for his scholarly activities throughout his
fellowship. Dr. Sala will meet with each mentor on at least a monthly basis as well as the full
committee on a semi-annual basis to oversee his multi-faceted training program.
Clinical training in the care of CF patients will be mentored by Dr. Jain and the Associate
Director of the Adult CF program, Dr. Michelle Prickett. Dr. Sala will participate in weekly
multidisciplinary clinics for adult cystic fibrosis patients at the Cystic Fibrosis Center of
Children’s Memorial Hospital (CMH) and at Northwestern Memorial Hospital (NMH). He will
also see patients in the transition CF clinic at Children’s Memorial. These clinics are comprised
of physicians, advanced practice nurses, nutritionists, physical therapists, social workers, and
respiratory therapists. When the adult cystic fibrosis patients are admitted to Northwestern
Memorial, Dr. Sala will assist in providing inpatient care for these patients under the guidance of
Drs. Jain or Prickett. He will also attend the weekly adult CF multi-disciplinary team meeting at
which patient related issues are discussed as well as ongoing QI and clinical research projects. In
addition he will attend the bimonthly combined adult and pediatric team meetings. With regards
to the clinical research aspect of his training, Dr. Sala will participate in multicenter clinical and
observational studies conducted through the Cystic Fibrosis Center. Dr. Sala will attend the
combined monthly clinical research meetings and will participate as a sub-investigator on many of
the trials.
Throughout fellowship, as part of his career development to becoming an independent
investigator, Dr. Sala has been developing a translational science research project to investigate
the role of c-Jun N-terminal kinases (JNKs) in modulating hypoxia-inducible factors (HIFs) in an
effort to mitigate pulmonary hypertension that results from many chronic lung diseases such as
CF, emphysema, interstitial lung disease. He will continue to pursue this interest and has two
additional grants pending review to support this aspect of his career development. Results he
obtains will form the basis for an abstract to be submitted to NACFC 2016.
StatusFinished
Effective start/end date7/1/166/30/19

Funding

  • Cystic Fibrosis Foundation (SALA16AC0)

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Cystic Fibrosis
Research
Mentors
Patient Care
Medicine
Pediatrics
Physicians
Patient Transfer
Translational Medical Research
Nutritionists
JNK Mitogen-Activated Protein Kinases
Organized Financing
Physical Therapists
Interstitial Lung Diseases
Emphysema
Critical Care
Pulmonary Hypertension
Biochemistry
Lung Diseases
Cell Biology