Fellowship in Support of Skeletal Metastasis in Prostate Cancer

Children of mothers who had diabetes mellitus during pregnancy or were diagnosed with gestational diabetes (i.e., diabetes that develops during pregnancy) have an increased risk of being obese or overweight in childhood, but, whether this risk is also present for higher levels of blood sugar less than those diagnostic of diabetes is not known. This project will address this and other questions by following up on a prior study in which the impact of mothers' blood sugar levels in the 3rd trimester of pregnancy on the birth outcomes of mothers and babies was determined in a large, multinational, racially diverse cohort of women and used to establish new guidelines for the diagnosis of gestational diabetes. In this study, we will recruit 7,000 mother-child pairs from the original study to determine whether a mother's blood sugar levels during pregnancy, including those newly diagnostic of gestational diabetes, are associated with measures of fatness in children and a mother's risk of abnormal blood sugar levels 8-12 years following the pregnancy, which could impact recommendations for the treatment and follow-up of mothers' blood sugar levels during pregnancy.