Project Details
Description
A critical mechanism driving the pathological progression of neurodegenerative disease is dysregulated inflammation in the brain. Neuroinflammatory repair processes are fundamental to CNS homeostasis. However, inflammation that is inefficient, excessive, or prolonged can result in tissue damage. Dysregulated neuroinflammation responses such as proinflammatory cytokine overproduction from abnormally activated glia are seen early in progressive neurodegenerative disorders such as Alzheimer’s disease (AD) and related dementias, and are a key contributor to synaptic dysfunction, neurodegeneration and cognitive decline.
Status | Finished |
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Effective start/end date | 9/30/18 → 5/31/21 |
Funding
- ImmunoChem Therapeutics, LLC (SP0047505, 10/31/18 // 4R44AG060846-02 REVISED)
- National Institute on Aging (SP0047505, 10/31/18 // 4R44AG060846-02 REVISED)
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