This is a translational research project that addresses perinatal brain injury using a mouse model. BMP signaling will be downregulated after HI injury by administering the drug Tamoxifen (Tam) to genetically engineered mice already present in our lab (NG2CreERT2; BMPR2fl/fl mice); upon receipt of this drug, expression of BMP receptor subunit 2 is blocked consequently preventing BMP signaling. The project will involve MRI and behavioral studies as well as histologic studies.
|Effective start/end date||9/1/12 → 8/31/14|
- Northwestern Memorial Foundation (Agmnt fully-executed 10/17/12)
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