Functional Neuroimaging of Nondeclarative Memory

Project: Research project

Project Details


Nondeclarative memory is a type of long-term memory that has been shown to support a variety of nonconscious cognitive skill learning tasks. Nondeclarative memory is generally observed as improvements in task performance without awareness of what was learned. Declarative memory, conscious memory for facts and events, is distinct from nondeclarative memory and is known to depend on the medial temporal lobe (MTL) memory system (including the hippocampus and adjacent cortical areas). Damage to the MTL due to acute injury or progressive disease (e.g., Alzheimer's disease) leads to impaired declarative memory but intact nondeclarative memory. For a number of nondeclarative memory tasks, it is not known what brain areas support learning or are involved in the expression of memory. The component cognitive processes that support nondeclarative memory are also poorly understood, particularly in the area of cognitive skill learning. The proposed program of research will use functional magnetic resonance imaging (MRI) to identify the neural substrates of three nondeclarative skill learning phenomena: category learning through prototype abstraction (Specific Aim 1), artificial grammar learning (Specific Aim 2) and perceptual-motor sequence learning (Specific Aim 3). In addition to identifying the brain areas that support memory in these tasks, stimulus-level contrasts will be used to identify the types of processing associated with successful task performance. Comparisons of patterns of evoked activity across the tasks are expected to identify processing differences between tasks that depend on cortically mediated facility-driven processing (e.g., dot-pattern categorization and priming) and tasks that depend on subcortical- cortical interactions (e.g., perceptual-motor sequence learning) which appear to operate through a retrieval mechanism (Specific Aim 4). In addition, declarative and nondeclarative memory will be directly compared across all three tasks to identify consisten
Effective start/end date7/6/006/30/06


  • National Institute of Mental Health (5 R01 MH058748-05 (Rev.9/27/04))


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