We hypothesize that female mice will exhibit a more suppressive tumor microenvironment (TME) compared to male mice as demonstrated by (1) enhanced early infiltration of T regulatory cells (Tregs) and myeloid derived suppressor cells (MDSCs); (2) reduced adaptive immune cell infiltration (e.g. B cell, type 1 helper (Th1) CD4+ T cell, CD8+ T cell) and (3) larger bladder tumor burden. By inhibiting these suppressive immune cells early in bladder tumor development, we predict restoration of adaptive immune cell infiltration and anti-tumor responsiveness (e.g. lower tumor burden).
|Effective start/end date||7/1/20 → 6/30/21|
- Society of Women in Urology (Meeks AGMT 2/12/21)
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