Project Details
Description
Irritability emerges during infancy, and is a substrate of many common forms of developmental psychopathology. However, reliable identification of irritable infants at high risk for clinical progression is challenging due to high levels of normative variation combined with substantial individual differences in adaptive or maladaptive outcomes for irritable infants over time. Building on our prior work at preschool age, the proposed study utilizes a neurodevelopmental framework to generate empirically-derived, parameters for differentiation of irritability patterns that mark risk for clinical progression. Key innovations are: (1) novel approach to specification of developmentally atypical patterns of irritability beginning in infancy; (2) joint developmental consideration of irritability, executive function and prefrontal cortical regions; and (3) transactional focus examining the clinical import of early irritability within the context of parent-infant mutual (dys)regulation. To derive population-based parameters, we first conduct a cross-sectional survey of a representative sample of 12-36 mos. olds (N=2,000). We then ascertain an independent community cohort (N=350 infants oversampled for irritability), with intensive longitudinal follow-up from 12-36 months. Focal irritability assessments are: (a) bi-monthly parent reports and real-time monitoring of irritable vocalizations via the Language Environment Analysis (LENA) Pro device; and (b) annual direct observations of irritable temperament and behavior (12, 24 & 36 mos). Performance-based assessments of executive function occur annually. Mutual regulation is assessed bi-monthly via LENA data on sequences of infant irritable vocalizations and parental responses and annually via event-coded parent-infant observed mutual regulation. Clinical progression is captured via latent dimensional clinical risk over time. SPECIFIC AIMS: IA. Differentiate developmentally atypical irritability patterns from infancy-early prescho
Status | Finished |
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Effective start/end date | 3/2/16 → 2/28/23 |
Funding
- National Institute of Mental Health (3R01MH107652-05S1)
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