Glioblastoma multiforme (GBM) remains one of the deadliest classes of human cancers with a median survival rate of approximately 12 to 15 months. Neural stem cells have the unique inherent property to migrate throughout the brain and target invasive solid tumors, including gliomas. This provides a novel platform for targeted delivery of anti-cancer agents to disseminated tumors selectively. The studies outlined in this proposal are geared towards understanding the molecular mechanisms of the tumor homing properties of neural stem cells and utilizing this information to enhance the targeting efficiency of novel neural stem cell-based therapeutic strategies for this disease. We believe that this proposed research plan has the potential to make an impact beyond neuro-oncology and will accelerate the translational of the stem cell-based therapy in the clinic.
|Effective start/end date||11/1/15 → 8/31/16|
- National Cancer Institute (7R00CA160775-05)