This proposal seeks to employ heme-containing metal-organic framework (MOF) materials to carry out the oxidative degradation of small molecules that serve as models of chemical warfare agents. Both gas- and solution-phase experiments will be pursued, using oxidants such as molecular O-atom transfer agents and gaseous dioxygen. These initial studies are intended to provide guidance for future work with actual warfare agents that will commence with collaborators at the U. S. Army Edgewood Chemical Biological Center, led by Dr. Christopher J. Karwacki. The materials developed in this project will serve to selectively oxidatively decompose chemical warfare agents, such as mustard gases and VX nerve agents, into benign forms. The materials could find use in filters of soldier masks, uniforms, or even safety shelters, and therefore offer to provide significant enhancements in warfighter safety and protection.
|Effective start/end date||4/15/15 → 1/14/16|
- Army Research Office (W911NF-15-1-0119)