SPECIFIC AIM: To elucidate the roles of B7H1 and CTLA-4 in glioma-mediated immunosuppression Challenge: To investigate and reverse the immunosuppressive roles of B7H1 and CTLA-4 in GBM. Approach: From human specimens, murine models, and cell culture lines; we will attempt to further characterize the immunosuppressive mechanisms and expression of B7H1 and CTLA-4 in GBM and low grade gliomas. Impact: The results obtained from this project will provide a natural extension of the current available pharmacological agents which inhibit B7-H1, PD-1, and CTLA-4.
|Effective start/end date||5/1/15 → 6/30/17|
- Howard Hughes Medical Institute (57008281)
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