HHMI Medical Research Fellow 2015-2016 (Fellow: Leonel Ampie)

  • Bloch, Orin (PD/PI)

Project: Research project

Project Details

Description

SPECIFIC AIM: To elucidate the roles of B7H1 and CTLA-4 in glioma-mediated immunosuppression

Challenge: To investigate and reverse the immunosuppressive roles of B7H1 and CTLA-4 in GBM.

Approach: From human specimens, murine models, and cell culture lines; we will attempt to further characterize the immunosuppressive mechanisms and expression of B7H1 and CTLA-4 in GBM and low grade gliomas.

Impact: The results obtained from this project will provide a natural extension of the current available pharmacological agents which inhibit B7-H1, PD-1, and CTLA-4.
StatusFinished
Effective start/end date5/1/156/30/17

Funding

  • Howard Hughes Medical Institute (57008281)

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