Homeobox Gene Six3 in Forebrain and Visual System Development

Project: Research project

Project Details

Description

Congenital retina abnormalities such retinal degenerative diseases cause varying degrees of irreversible vision
loss in millions of people worldwide. Although recent advances in our understanding of retinal development
have facilitated the use of screening protocols to detect mutations in genes associated with those ocular
diseases, no therapeutic approach is yet available. A conserved network of transcription factors is essential for
eye formation. The homeobox-containing gene Six3 is one of the members of that complex network that
regulates visual system development. Conditional removal of Six3 from the developing mouse eye field is
sufficient to arrest NR specification; a result demonstrating the critical role of Six3 during vertebrate retina
development. The work proposed in this application builds on our previous findings and our generated mouse
models to expand our knowledge about the processes leading to the formation of the visual system.
StatusFinished
Effective start/end date12/1/1511/30/16

Funding

  • Kennedy Institute - National Eye Clinic (7R01EY012162-17 REVISED)

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