Hybrid biomolecular synapses for multifunctional sensing and neuromorphic computing at the edge of biology

Project: Research project

Project Details

Description

The goal of the proposed project is to develop fundamental understanding for a new type of multifunctional neuromorphic interface—a hybrid biomolecular synapse—capable of selective ionic and biochemical sensing, signal processing, learning, and memory in wet, cellular environments. The proposed hybrid device pairs a biomembrane containing stimuli-responsive biomolecules (e.g., transmembrane ion channels or receptors) with a semiconducting polymer. This integration aims to unite the diverse multifunctionality and molecular specificity of biomolecules for chemical sensing, selective transport, and stimuli- responsive signaling with the mixed ionic-electronic (ionotronic) transport in conductive polymers that allow them to operate as conformal electrodes, neuromorphic transistors, and in situ signal amplifiers. We hypothesize that integrating these components will: 1) yield biocompatible devices—including implantable, wearable, and conformal types of devices—that can transduce multiple types of physical stimuli using a biomimetic interface; and 2) enable tunable synapse- and neuron-inspired signal processing and memory functionalities. These advances are necessary to unlock ionotronic-biomolecular hardware for adaptive sensing, learning, and computing in close proximity to and in direct communication with living cells and tissue—at what we call the edge of biology
StatusActive
Effective start/end date9/30/229/29/27

Funding

  • University of Tennessee (A23-0483-S001 AMD 1 // FA9550-22-1-0426)
  • Air Force Office of Scientific Research (A23-0483-S001 AMD 1 // FA9550-22-1-0426)

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