Identification of the genetic basis of altered T cell receptor signaling in cutaneous T cell lymphoma

Project: Research project

Description

We propose the following Specific Aims:
1. To elucidate the role of CTCL mutations on T cell receptor signaling.
2. To define the role of CTCL mutations on TCR-dependent proliferation and production of immunosuppressive factors.
StatusFinished
Effective start/end date7/1/166/30/19

Funding

  • Doris Duke Charitable Foundation (Grant 2016095)

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Cutaneous T-Cell Lymphoma
T-Cell Antigen Receptor
Mutation
Immunosuppressive Agents