Identifying Therapeutic Biomarkers of Proteasome Inhibitor Efficacy in Glioblastoma

Project: Research project

Project Details


Glioblastoma (GBM) is the most common malignant primary brain tumor, with a median survival of only 21 months. Despite decades of research, the prognosis for GBM patients remains poor, and treatment options are limited. Recently, proteasome inhibitors have emerged as a promising therapeutic modality; however, several clinical trials have shown that only a subset of GBM patients responds to this treatment, and it is still unclear why. Our lab has previously shown that some proteasome subunits may have pro-carcinogenic functions outside their canonical roles in the ubiquitin-proteasome system, which may explain why this therapy does not work in all patients. Thus, this project aims to utilize unbiased CRISPR-Cas9 screening techniques to determine which proteasome subunits display these novel functions. By identifying which proteasome subunits harbor extra-proteasomal driver functions, we may be able to elucidate therapeutic biomarkers and ultimately increase the pool of patients that could benefit from this promising therapy.
Effective start/end date5/31/2211/30/22


  • Neurosurgery Research and Education Foundation (Ahmed AGMT 6/21/22)


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