IL13Rα2-directed SEA/E-120 for therapeutic T cells targeting to Glioblastoma

Project: Research project

Project Details

Description

In this proposal, we will investigate the therapeutic properties of recombinant fusion protein directed to tumor-associated antigen, IL13Rα2, via scFv47 attached to a mutated form of superantigen staphylococcal enterotoxin E (SEA/E-120) in murine glioma models of disease.
The NeoTx will provide purified recombinant protein and corresponding negative control protein for analysis.
The Northwestern University (PI: Irina Balyasnikova) will perform validations of the activity of the recombinant protein in murine models of glioblastoma in vitro and in vivo.
StatusActive
Effective start/end date12/1/2011/30/21

Funding

  • Neotx Holdings Ltd. (Agmt 12/01/20)

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