IL13Ra2-directed SEA/E-120 for therapeutic T cells targeting to Glioblastoma

Project: Research project

Project Details


In this proposal, we will investigate the therapeutic properties of recombinant fusion protein directed to tumor-associated antigen, IL13Rα2, via scFv47 attached to a mutated form of superantigen staphylococcal enterotoxin E (SEA/E-120) in murine glioma models of disease. The NeoTx will provide purified recombinant protein and corresponding negative control protein for analysis. The Northwestern University (PI: Irina Balyasnikova) will perform validations of the activity of the recombinant protein in murine models of glioblastoma in vitro and in vivo.
Effective start/end date12/1/202/28/23


  • Neotx Holdings Ltd. (Amendment #2)


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