Thermoradiotherapy refers to treatment modalities that involve supplementing radiotherapy with a thermal component for the purpose of augmenting radiosensitivity in targeted tissues. Th long-term goal of this proposal is to use thermoradiotherapy to improve the prognosis of patients receiving radioembolization for unresectable hepatic malignancies. Radioembolization is a selective internal radiation therapy that vascularly directs brachytherapy with yttrium-90 microspheres to targeted hepatic tumors, allowing for a high, localized radiation dose with minimal radiation exposure to healthy tissues and a low toxicyt profile. The objective of this proposal is to develop an image-guided technique to deliver localized hyperthermia for the enhancement of tumor radiosensitivity during radioembolization procedures. I have previously targeted tumors with iron oxide yttrium microparticles (IO-YAS) and accomplished highly localized delivery ofintratumoral hyperthermia with alternating magnetic field (AMF) exposure in the NI-S1 rodent HCC model. We propose using these IO-YAS compositions for magnetic targeting, MR imaging, and thermoradiotherapy while studying therapeutic efficacy in compositions for magnetic targeting, MR imaging, and thermoradiotherapy while studying therapeutic efficacy in cell culture and the rabbit VX2 hepatocellular carcinoma (HCC) model.
|Effective start/end date||9/1/13 → 12/1/15|
- SIR Foundation (Agmt Signed 9/6/13)
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