This proposal outlines in vitro experiments designed to demonstrate efficacy of antisense oligonucleotides (ASO) to target KCNQ2-p.H228R in human induced pluripotent stem cell (hiPSC)-derived cortical excitatory neurons using a combination of molecular biological and electrophysiological approaches.
|Effective start/end date||8/1/19 → 12/31/19|
- Lydian Accelerator (Agmt. 7/7/2019)
Induced Pluripotent Stem Cells
In Vitro Techniques