Induction of Antigen-Specific Tolerance in Autoimmune Diabetes with Nanoparticles containing Hybrid Insulin Peptides

Project: Research project

Project Details

Description

The Miller lab will be responsible for preparing the Ag-coupled and Ag-encapsulating biodegradable PLG nanoparticles to be used for tolerance induction by both the Haskins and Miller labs. The lab, in parallel with studies to be done in the Haskins lab will test tolerance induction in spontaneous T1D in both wildtype NOD mice and in the BDC2.5 and NY8.3 transgenic T cell transfer systems using the various endogenous, mimetope and hybrid diabetogenic epitopes and in the islet transplant model. The lab will be primarily responsible for determining the contributing roles role of anergy and Tregs in tolerance induced by Ag-PLG nanoparticles including experiments determining the role of the PD-L1/PD-1 and CTLA-4 co-inhibitory pathways in tolerance induction and maintenance.
StatusFinished
Effective start/end date2/1/208/14/20

Funding

  • University of Colorado Denver (2-5-A8908)
  • JDRF International (2-5-A8908)

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