One of the hallmarks of human uniqueness is our ability to inhabit a wide range of environments. Human phenotypic and behavioral plasticity and the ability to extensively modify our environments through niche construction, have allowed us to be the most widely dispersed primate 1,2. As humans have moved into these varied environments, a diversity of diets, behavioral adaptations, cultural practices, and technologies have emerged 3. Additionally, genomic adaptation to local environments led to population- and region-specific genetic variants in humans 2,4. The gut microbiome both is heavily influenced by the external environment and acts as mechanism contributing to human phenotypic plasticity. The proposed study examines how human gut microbial function have been shaped by a transition to agriculture and local adaptation.
|Effective start/end date||8/1/19 → 7/31/21|
- Canadian Institute for Advanced Research (Letter CP20-008, Catalyst Project CF-0095)