Project Details
Description
Similar to our data in mouse models of autoimmune disease, we hypothesize that tolerance will be induced in human naïve and previously activated CD4 and CD8 T cells in humanized NSG mice using diabetogenic antigens/peptides encapsulated within carboxylated PLG nanoparticles. To test this hypothesis, we will carry out the following three specific aims over a two year period:
Aim 1: Establishment of humanized NSG mouse model of responses to diabetogenic Ags
Aim 2: Proof of principle that Ag-PLG particles can establish tolerance in human T cells
Aim 3: Determination of the mechanistic basis of tolerance in human T cells in humanized NSG mice
| Status | Finished |
|---|---|
| Effective start/end date | 12/3/13 → 11/30/15 |
Funding
- Novo Nordisk Inc. (Agmt 12/03/13)
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