Integrative Multi-Scale Systems Analysis of Gene-Expression-Driven Aging Morbidity

The ability to sustain gene expression homeostasis, is one of the most integral parts of cellular biology but declines with age. In a well-received preprint the project investigator discovered that most organs of 24 months old mice display a genome-wide imbalance in the transcript levels encoded by short genes relative to those encoded by long genes. This project will address the regulation of this transcriptome imbalance and its impact on the functional health of the proteome and the multi-morbidity in aged individuals.