Intrinsic-contrast super-resolution imaging of DNA at 2-nm resolution

One of the major recent scientific breakthroughs was the emergence of super-resolution optical nanoscopy. We will develop a new optical nanoscopy technology that will enable thus far unattainable direct imaging of cellular structure with nanometer resolution. The technology could have a profound impact on a wide range of biomedical research as we will be able to study macromolecular cellular processes and their alterations in disease in their natural state.