Investigating nanoscale neuronal damages in early glaucoma towards clinical optical detection

This proposal aims to develop a new clinical imaging modality, referred to as visible-light optical coherence tomography or vis-OCT, to achieve early and objective glaucoma detection. The new imaging technology offers much improved spatial resolution and imaging sensitivity as compared with the state-of-the-art clinical OCT systems. The PIs will accomplish the proposed work in two mouse models of experimental glaucoma and will work with leading clinicians to translate findings towards patient imaging.