Investigating prestin's role in outer hair cell survival

Project: Research project

Project Details

Description

The objective of this study is to investigate how prestin contributes to survival of outer hair cells, the outcome of which could allow development of a novel strategy to reduce hearing impairment. Prestin is the voltage-dependent molecular motor responsible for the somatic electromotility of outer hair cells (OHCs) (17). That this process is essential for sensitivity and frequency selectivity in mammals was demonstrated using mouse models lacking prestin (knockout (KO), (1, 8)) or expressing mutated
prestinV499G/Y501H (referred to as “499-prestin” knockin (KI) with impaired motor function (3, 6, 16)). Quite unexpectedly, it was discovered that these mice suffer premature OHC loss, implying prestin functions
not only for cochlear amplification but also for OHC survival. We hypothesize that prestin’s voltagedependent motor activity is also used as a “shock absorber” to alleviate mechanical stress imposed on OHCs, which is exacerbated by their attachment to the tectorial membrane (TM), and
that the OHC death seen in prestin-KO and 499-prestin-KI mice is ascribed to the loss of this shock-absorbing function. Our hypothesis stems from the following preliminary data.
StatusFinished
Effective start/end date2/3/142/2/16

Funding

  • Capita Foundation (Award Letter 12/23/13)

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