Investigating T-cell signature and clonality of food triggers in Eosinophilic Esophagitis

Project: Research project

Project Details

Description

Eosinophilic Esophagitis (EoE) is a chronic disease where foods trigger inflammation in the esophagus. Empiric elimination diets have been utilized to identify triggers as no testing exists that is effective. We propose to examine esophageal biopsies for evidence of the specificity of immune response of white blood cells to specific foods. We will use deep sequencing of the T-lymphocyte receptor to identify how frequent unique types of T-cells exist. This would explain the education of the immune system for specific foods and provide a potential screen.
StatusFinished
Effective start/end date7/1/186/30/19

Funding

  • Northwestern Memorial Hospital (Agmt#14 Signed 10/18/18)
  • Digestive Health Foundation (Agmt#14 Signed 10/18/18)

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