The overall objective of this proposal is to test the hypothesis that THAP11-HCF1 functions by regulating a novel set of target genes in breast cancerprogression. The extended objective is to develop this application further with support from Lynn Sage Foundation for consideration as a key project in SPORE submission by our cancer center. The specific goal is to determine the target gene signature of HCF1 and to unequivocally establish that THAP11-HCF1 is a novel regualtor of breast cancer cell proliferation and metastasis. Knowledge obtained from the proposed studies should help in future rational drug design targeting THAP11-HCF1 complex and its transcriptone.
|Effective start/end date||9/1/12 → 8/31/14|
- Northwestern Memorial Foundation (Agmt 9/25/12)