The objective of this proposed research is to clarify the role of neuroinflammation in LATE clinical disease progression. We will investigate TDP43 associated inflammatory markers relevant to pathways of interest, co-existing neuropathologic lesions, LATE genetic risk variants and cognitive performance data in well-characterized samples from Mayo Clinic. This work will inform on the role of TDP43-associated neuroinflammation in the development of cognitive impairment and dementia in late life and ultimately, enable the development of future preventative and therapeutic interventions. This research will provide some of the first information about neuroinflammation in LATE.
|Effective start/end date||9/15/20 → 5/31/25|
- National Institute on Aging (1K08AG065463-01)