Karl Kirchgessner Foundation Vision Research Grant

Project: Research project

Project Details

Description

Developing a deeper understanding of brain function requires researchers to connect the different levels of
analysis that have characterized the field of neuroscience. In particular, the frontier of systems neuroscience is
to reveal how the biophysical properties of neurons and the pattern and characteristics of their synaptic
connections together give rise to a functional neural circuit. Measurements of neuronal biophysics, anatomical
connectivity, synaptic currents, and circuit function are rarely performed on the same cells, and this
experimental limitation has been a barrier to our integration of knowledge across these different levels. My
proposal describes a new technique to measure anatomical connectivity, synaptic properties, and circuit output
all in the same neurons and a new conceptual framework to integrate these measurements into a model to
predict circuit function given its natural input. The neural circuits of the mouse retina provide an ideal model
system for this integrated approach because of our nearly complete knowledge of cell types and the
experimental accessibility of the retina, in which it can be stimulated with its natural input (patterns of light)
while recording its full output (the spike trains of retinal ganglion cells). In addition to their impact as templates
for the integration of measurements across levels to predict circuit function, the circuit maps of the mouse
retina will provide critical insights into the segregation of visual processing between the retina and downstream
visual areas in the brain and provide insights for the diagnosis and treatment of retinal disease.
StatusFinished
Effective start/end date12/1/1411/30/16

Funding

  • Karl Kirchgessner Foundation (Agmt 12/3/14)

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