Long-term Outcomes of Knee OA in the OAI Cohort

Knee OA is a major cause of pain, functional limitation and disability, but there are critical gaps in knowledge about the long-term clinical course of the disease and its determinants. We propose to extend the follow-up for knee OA outcomes in the entire Osteoarthritis Initiative Cohort from 8 to16 years in order to assess a broad range of long-term health outcomes of knee OA and to identify potentially modifiable predictors of poor and successful outcomes, using an approach that addresses important challenges in the study of disease progression.