Lung transplant injury drives chronic lung allograft dysfunction via recruitment of monocyte-derived alveolar macrophages

Early events after the lung transplant procedure, such as surgical trauma and ischemia-reperfusion injury, play a crucial role in setting the stage for subsequent chronic lung allograft dysfunction. Monocytes, recruited during the lung injury, can differentiate into monocyte-derived alveolar macrophages and drive development of CLAD. In this application, using causal murine models and unique human material from patients with CLAD, we will dissect molecular signals responsible for maintenance of these pathogenic monocyte-derived alveolar macrophages in patients with CLAD.