Lymph Vessels in Obesity and Cardiovascular Disease

Project: Research project

Project Details

Description

Obesity and cardiovascular disease are leading causes of death and disability in the
developed nations. Current treatments for these diseases target biological processes involving the
heart, blood vessels, and other organs directly affected. Although such treatments have improved
outcomes, the development of new therapies requires the identification and validation of new
pathogenetic mechanisms. The lymphatic vascular system is required to maintain tissue fluid balance,
to absorb intestinal fats and to coordinate immune responses. In the past, the biological roles of
lymphatic vessels were considered distinct from those of blood vessels, but recent studies by the
members of this network and others suggest that lymphatic vessel function impacts directly on
obesity, vessel wall inflammation, atherosclerosis and thrombosis. In this proposal we will determine
how lymphatic malfunction promotes these conditions and their impact in cardiovascular disease.
StatusFinished
Effective start/end date7/22/1512/31/17

Funding

  • Leducq Foundation (11CVD03)

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