Development of Novel Therapeutic Strategies for Aggressive CTCL Subtypes

Project: Research project

Project Details

Description

Unbiased transcriptome analysis suggests that CTCL exhaustion is a durable (but reversible) transcriptional and metabolic state. In this proposal, we plan on coupling high-dimensional assays and genome-wide screens to systematically identify the genes and pathways that are necessary to enforce or reverse the exhaustion phenotype. Successful completion of this grant will enable us to identify 1) the genes/pathways necessary and sufficient to reverse CTCL exhaustion and 2) novel therapeutic strategies for aggressive PD1-mutant CTCLs.
StatusFinished
Effective start/end date7/1/196/30/21

Funding

  • Damon Runyon Cancer Research Foundation (Award Letter 5/17/19)

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