MACC/EPICC-Net as a Hub for the HEAL Initiative EPICC-NET

Project: Research project

Project Details

Description

EXECUTIVE SUMMARY: Early Phase Pain Investigation Clinical Network (EPPIC-Net)The purpose of this funding opportunity announcement (FOA) is to invite applications for the Specialized Clinical Centers (“hubs”) of the Early Phase Pain Investigation Clinical Network (EPPIC-Net). EPPIC-Net will serve as the cornerstone of the NIH’s Helping to End Addiction Long-term (HEAL) Initiative. EPPIC-Net will provide a robust and readily accessible infrastructure for carrying out in-depth phenotyping and biomarker studies in patients with specific pain conditions, and the rapid design and performance of high-quality Phase 2 clinical trials to test promising novel therapeutics for pain from partners in academia or industry. Studies will bring intense focus to patients with well-defined pain conditions and high unmet therapeutic needs.EPPIC-Net will consist of one Clinical Coordinating Center (CCC), one Data Coordinating Center (DCC) and approximately 10 specialized clinical centers (“hubs”). The purpose of this funding opportunity announcement (FOA) is to invite applications for the hubs within EPPIC-Net. A hub will typically be a regional medical center that will actively enroll subjects into clinical trials and studies performed in EPPIC-Net. Each hub should have ready access to patient populations with specific pain conditions and have expertise in characterization of that pain condition. A hub will additionally provide scientific leadership and administrative oversight to its multiple (2-10) satellite sites (“spokes”).This FOA solicits applications EPPIC-Net Specialized Clinical Centers. Separate FOAs have been issued to solicit applications for the Clinical Coordinating Center (RFA-NS-19-023) and Data Coordinating Center (RFA-NS-19-024). Clinical trials conducted through EPPIC-Net may come from a variety of sources including the HEAL Partnership, as described above, or from separate NIH funding announcements.The RFA (RFA-NS-19-036) can be accessed at: https://grants.nih.gov/grants/guide/rfa-files/RFA-NS-19-036.htmlThe Medical College of Wisconsin is submitting an application in response to this RFA, using the established SIREN Mid-America CTSA Consortium (MACC) as its Hub and Spoke network, capitalizing on its comprehensive clinical research infrastructure and proven translational research performance. Each center in the MACC consortium will use its local site PI and add an additional pain management expert to its existing clinical research infrastructure for implementation of EPPIC-Net clinical trials. Participation in EPPIC-Net provides minimal infrastructure support, but offers “pay for performance” funding for entry of study patients, a pipeline of ongoing clinical trials, and access to HEAL Initiative funding for independent clinical trials.
StatusActive
Effective start/end date9/1/203/31/24

Funding

  • Medical College of Wisconsin (AGMT 5/20/21// 1U24NS115679-01)
  • National Institute of Neurological Disorders and Stroke (AGMT 5/20/21// 1U24NS115679-01)

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