Childhood obesity is a major public health problem affecting close to 20% of children in the United States. Fetal programming of adult disease, in which the maternal nutritional environment during pregnancy has an impact on life-long health status of offspring, is one proposed mechanism underlying this obesity epidemic. We propose to study the importance of vitamin D levels during pregnancy in understanding the risk of obesity development during the childhood years, and explore fetal vitamin D exposure as it relates to newborn body fat. The Hyperglycemia and Adverse Pregnancy Outcomes (HAPO) Study was a large, multicenter study of glucose levels during pregnancy, results of which have changed the diagnostic criteria for diabetes in pregnancy. The HAPO Follow Up Study is now underway with the main objective to determine if body fat measurements in the newborn period are predictive of body fat measurements at age 10 years. The goal of the current proposal is to evaluate associations between vitamin D levels in stored cord blood and newborn percent body fat in a sample of 300 HAPO Study participants. Results of this analysis will serve as critical preliminary data for an NIH grant application to study maternal fetal programming of vitamin D as it relates to obesity risk in the HAPO Follow Up Study Cohort.
|Effective start/end date||9/1/13 → 8/31/16|
- Northwestern Memorial Hospital (Exhibit B.9)