Measuring Electrical Activity from the Human Brain to Predict Memory Formation and Behavior Across the Lifespan

Memory is core to human cognition, undergoes protracted developmental maturation and age-related decline, and is disrupted in numerous neurological and neuropsychiatric disorders. Despite the central role of memory in health and disease, remarkably little is known about the neural mechanisms supporting memory across the human lifespan. This R00 project will combine rare intracranial recordings from neurosurgical patients and advanced electrophysiological data analysis to track memory formation and maintenance in real time, and predict behavior in children, adolescents, and adults. With these spatiotemporally precise measures of memory formation and maintenance, this research will address critical gaps in knowledge about this core neurocognitive function. Comparative analysis between intracranial recordings and scalp electroencephalography (EEG) measures will further identify noninvasive EEG metrics applicable to developmental, lifespan, and disease-related research.