Mechanisms of Leukemogenesis in Down Syndrome

Project: Research project

Project Details

Description

Children with Down syndrome, who have three copies of chromosome 21, face a 500-fold increased risk of
developing acute megakaryoblastic leukemia and a 20-fold increased risk of pre-B cell acute lymphoblastic
leukemia. Our research will uncover the mechanisms by which three copies of two genes on chromosome 21,
the kinase DYRK1A and the chromatin assembly factor CHAF1B, contribute to normal and malignant
hematopoiesis. Our work will also aid in the development of new, targeted therapies for these leukemias.
StatusActive
Effective start/end date5/1/174/30/22

Funding

  • National Cancer Institute (5R01CA101774-18)

Fingerprint

Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.