Mechanisms of regulatory T cell-mediated endothelial repair following viral pneumonia in aged hosts

Project: Research project

Project Details

Description

Influenza A virus (IAV) infection and pneumonia represent the leading infectious causes of death in the United States, and disproportionally affect the elderly. Regulatory T (Treg) cells coordinate the resolution of lung injury, but the mechanisms underpinning the loss of pro-endothelial repair function in Treg cells from aged hosts remains unknown. We aim to uncover the transcriptional and functional changes that determine the gain and loss of pro-endothelial cell repair function in Treg cells following viral pneumonia throughout the lifespan.
StatusFinished
Effective start/end date7/1/219/30/21

Funding

  • Francis Family Foundation (PBF Notice of Award, rev. 7/20)

Fingerprint

Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.