N4-acetylcytidine (ac4C) is an RNA modification catalyzed by the enzyme NAT10. NAT10 is dysregulated and promotes proliferation in multiple cancers including acute myeloid leukemia (AML). Thus, this proposal will expand our knowledge on how NAT10-catalyzed ac4C promotes proliferation in cancer cells and will provide solid foundations to furnish novel therapeutic strategies in AML.
|Effective start/end date||9/1/21 → 8/31/24|
- National Cancer Institute (4R00CA245035-02)
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