Mechanisms Underlying Sleep Disturbances in Parkinson's Disease

Project: Research project

Project Details

Description

Our proposed work focuses on the FY19 PRP Focus Area of “Sleep Biology in Parkinson’s Disease”. Disrupted sleep is one of the most common yet poorly understood non-motor symptoms of Parkinson’s disease (PD). It has been estimated that up to 90% of the PD patients suffer from at least one form of disordered sleep, most commonly fragmented sleep (i.e., frequent arousal from sleep), insomnia (i.e., troubles in initiating or maintaining sleep), excessive daytime sleepiness, and rapid-eye-movement sleep behavioral disorder (RBD, e.g., excessive activities during rapid-eye-movement sleep, acting out dreams). With a typically early-onset and progressively worsened symptoms, disrupted sleep is a major contributor to the declined quality of life in PD patients. However, mechanisms underlying these sleep disturbances remains largely unclear. The lack of understanding of such mechanisms hinders the development of specific treatments that alleviate PD-associated sleep disturbances. Indeed, many aspects of sleep disturbances in PD patients are not sufficiently controlled and some can even be exacerbated by commonly used PD treatments.
StatusActive
Effective start/end date9/30/219/29/25

Funding

  • U.S. Army Medical Research and Materiel Command (W81XWH2110582)

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