Mechanistic insights into the deleterious effects of SIRT2 in the heart under stress conditions

Heart failure is highly prevalent in developed countries, but the underlying mechanism for this disorder is not well characterized. Sirtuin (SIRT) family of proteins modify other proteins within the cell by removing acetyl groups and altering their function. One member of this family, SIRT2, has not been studied in the heart, and in this proposal, we will assess its role in cardiac response to pressure overload, through its regulation of NRF2 protein activity.