Metabolite Markers of Coffee Consumption and Risk of Type 2 Diabetes

Coffee is one of the most widely consumed beverages in the world and thus represents a significant opportunity to positively affect T2D globally. The combination of advanced metabolomic methodology applied to plasma samples drawn from a controlled trial of coffee intake and a well-characterized cohort of women with rich data on diet, lifestyle, and genetics, represents an unprecedented opportunity to address the proposed aims in an extremely cost-effective manner. Narrowing in on the precise protective constituents and characterizing factors that modulate their physiological levels may provide insight to the role this beverage plays in T2D development, enhance the way coffee is studied in a population and further contribute to development of new strategies for the prevention and treatment of this disease.