Mild Cognitive Impairment and Endurance Exercise in Parkinson’s Disease

This is a research study about high intensity endurance exercise for people with Parkinson’s disease and Mild Cognitive Impairment (PD-MCI), conducted under the supervision of Dr. Jennifer G. Goldman at Rush University Medical Center and Dr. Daniel Corcos at Northwestern University. The investigators are interested in understanding how high intensity endurance exercise improves both cognition and the signs and symptoms of Parkinson’s disease, as well as if certain brain structures and functions also change with this exercise. The research will: 1) determine if high intensity endurance exercise improves cognitive function and other clinical symptoms in PD-MCI, 2) look at how high intensity endurance exercise changes the structure, function, and connectivity in the brain, and 3) determine the effect of high intensity endurance exercise on cortisol (a hormone) in PD-MCI.