MiR-21 and the regulation of neuronal degeneration in Alzheimer’s Disease

Project: Research project

Description

Specific aim(s)/objective(s):
We hypothesize that the loss-of-function of miR-21 contributes to the deregulation of genes involved in neurodegeneration Alzheimer’s disease (AD) and related disorders. To test this hypothesis, we proposed to: 1) assess the expression of miR-21 in AD and other tauopathy subjects; and 2) analyze to what extent changes in miR-21 levels alter neuronal survival of hippocampal neurons exposed to beta-amyloid (Aβ) oligomers.
StatusFinished
Effective start/end date7/1/166/30/17

Funding

  • Illinois Department of Public Health (73282002E)

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Alzheimer Disease
Tauopathies
Amyloid
Neurons
Genes