miR-342, a novel glucocorticoid-responsive miRNA necessary for Foxp3+ regulatory T cell function

Based on the compelling evidence, we propose the hypothesis that miR-342 is a Treg cell-specific, glucocorticoid-induced miRNA that plays a regulatory role in Treg cells’ ability to control inflammation. Two specific aims are proposed. First, we will determine the role of miR-342 in Treg cell functions. Two newly generated animal models in which Treg cells lack or overexpress miR-342 will be used. Second, we will examine the role of Treg cell-derived miR-342 in steroid resistance. Identification of the mechanisms by which glucocorticoid-induced miR-342 regulates Treg cell functions will open novel opportunities to develop therapies applicable to manage severe inflammatory conditions including steroid resistance.