Based on the compelling evidence, we propose the hypothesis that miR-342 is a Treg cell-specific, glucocorticoid-induced miRNA that plays a regulatory role in Treg cells’ ability to control inflammation. Two specific aims are proposed. First, we will determine the role of miR-342 in Treg cell functions. Two newly generated animal models in which Treg cells lack or overexpress miR-342 will be used. Second, we will examine the role of Treg cell-derived miR-342 in steroid resistance. Identification of the mechanisms by which glucocorticoid-induced miR-342 regulates Treg cell functions will open novel opportunities to develop therapies applicable to manage severe inflammatory conditions including steroid resistance.
|Effective start/end date||1/18/23 → 12/31/24|
- National Institute of Allergy and Infectious Diseases (1R21AI172135-01A1)
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