Modeling the role of the genome in chemotherapy induced cardiotoxicity using iPSC

Project: Research project

Project Details

Description

Doxorubicin is a highly effective chemotherapy drug the use of which is complicated by its well-established cardiotoxic side effect, with little potential for predicting which patients will be adversely affected. In this project, we are investigating the application of human induced pluripotent stem cell-derived cardiomyocytes to validate genetic markers of doxorubicin-induced cardiotoxicity and to establish the molecular mechanisms by which they alter the risk of this complication. This knowledge should be of value in prediction of doxorubicin-induced cardiotoxicity and this platform useful for studying means of prevention.
StatusFinished
Effective start/end date9/1/158/31/18

Funding

  • National Heart, Lung, and Blood Institute (5R00HL121177-04)

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