Modulating the Cochlear Proteostasis Network to Prevent Hidden Hearing Loss

Project: Research project

Description

The goal of this project is to develop a noninvasive therapeutic strategy to protect US Service members from noise induced hearing loss (NIHL). To achieve this goal we will focus on testing the therapeutic potential of several molecular targets identified in our preliminary studies and determining their modes of action. NIHL is one of the most common occupational illnesses in the US affecting 12% of adolescents and 17% of adults. Currently, surgery cannot correct NIHL and there are no effective medicines available. NIHL is caused by damage to cells within the inner ear that detect sound and transmit the information to the brain. Exposure to intense levels of sound is common while serving in the military and can cause temporary or permanent hearing loss. Recently, it was unexpectedly found that many US service members acquire NIHL despite having normal hearing tests. This phenomenon, now called “hidden hearing loss”, represents a major health crisis for both the US Service members and the American public at large.
StatusActive
Effective start/end date9/1/198/31/22

Funding

  • U.S. Army Medical Research and Materiel Command (W81XWH1910627)

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Noise-Induced Hearing Loss
Cochlea
Hearing Loss
Hearing Tests
Occupational Diseases
Inner Ear
Health
Brain
Therapeutics